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Collapse AMP 2016 Annual Meeting Highlights - CHIPping Away at the Mysteries of Hematopoiesis: The Science and Clinical Implications of Clonal Hematopoiesis of Indeterminate Potential

Please note that this webinar was recorded in 2016. All AMPEDTM content is reviewed and approved annually by the Training & Education Committee as relevant and accurate, but new data may now be available and new studies may have since been published.

AMP Education is constantly updating these educational offerings, so keep checking back at educate.amp.org for new content, content updates, and information on cutting-edge molecular pathology research and applications.

This collection will give you access to the recordings of the presentations (listed below) and pdf slides only. CME/CMLE or SAM is not available for this collection


Description:

Did you miss out on joining us in Charlotte for the AMP 2016 Annual Meeting? Were you there but missed something you really wanted to see? We have you covered with the AMP 2016 Annual Meeting Highlights. Select presentations were recorded and are now available for online viewing.

 

CHIPping Away at the Mysteries of Hematopoiesis: The Science and Clinical Implications of Clonal Hematopoiesis of Indeterminate Potential

The concept of a pre-cancerť clonal proliferation is fundamental to our understanding of the natural evolution of a variety of cancer types and an active area of research. Recent recognition of pre-malignant clonal hematopoiesis has been yet another exciting discovery in this area. The speakers will discuss their work in identifying Clonal Hematopoiesis of Indeterminate Potential (CHIP) and its relationship to both aging and the subsequent development of recognized hematopoietic malignancies.

- Explain the concept of clonal hematopoiesis.

- Describe how clonal hematopoiesis can be evaluated using markers identified by high-through sequencing.

- Summarize current knowledge regarding the association between clonal hematopoiesis and the development of recognized hematopoietic cancers, particularly myelodysplastic syndromes.

 

Clonal Hematopoiesis of Indeterminate Potential

Benjamin Ebert, MD, PhD, Brigham and Women's Hospital

CHIP, ICUS, MDS: A Clinical Perspective

David P. Steensma, MD, Dana-Farber Cancer Institute, Boston, MA, USA

 

Duration1.5 hr

Recording Date: November 10, 2016


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Note: Join the AMP Family to purchase this content for a deep discount!

 

Formats Available: AMP 2016 Highlights - Ebert & Steensma
Original Course Date: November 10, 2016
On-Demand Release Date: Available Now
MORE INFOMORE INFO AMP 2016 Annual Meeting Highlights - CHIPping Away at the Mysteries of Hematopoiesis: The Science and Clinical Implications of Clonal Hematopoiesis of Indeterminate Potential
Collapse AMP 2016 Annual Meeting Highlights - Design, Validation, and Implementation of Effective Quality Control Materials for NGS/NIPS in a Clinical Laboratory
Recordings of Selected Presentations

Please note that this webinar was recorded in 2016. All AMPEDTM content is reviewed and approved annually by the Training & Education Committee as relevant and accurate, but new data may now be available and new studies may have since been published.

AMP Education is constantly updating these educational offerings, so keep checking back at educate.amp.org for new content, content updates, and information on cutting-edge molecular pathology research and applications.

This collection will give you access to the recordings of the presentations (listed below) and pdf slides only. CME/CMLE or SAM is not available for this collection


Description:

Did you miss out on joining us in Charlotte for the AMP 2016 Annual Meeting? Were you there but missed something you really wanted to see? We have you covered with the AMP 2016 Annual Meeting Highlights. Select presentations were recorded and are now available for online viewing.

 

Design, Validation, and Implementation of Effective Quality Control Materials for NGS/NIPS in a Clinical Laboratory

As tests for large numbers of rare genetic conditions come on-line in clinical laboratories, it is becoming increasing difficult to obtain high-quality, well-characterized human samples to use for the purposes of test development, validation, and ongoing proficiency testing. The first presentation will review how the CDC GeT-RM program is helping laboratories access samples for these purposes. Non-invasive prenatal screening (NIPS) for the common triploidies, Down (T21), Edward (T18) and Patau (T13) syndromes, as well as numerical abnormalities of the sex chromosomes, is now firmly established as an extremely valuable screening tool. However, there is currently no universally accepted or adopted proficiency test (PT) for NIPS. The second presentation will review the substantial challenges in developing PT for NIPS, and review progress in its development.

- Identify the sample resources available to laboratories through the Get-RM program.

- Explain the challenges and current progress toward developing PT samples for NIPS testing.

 

Development of Reference Materials for Proficiency Testing and Quality Assurance

Lisa V. Kalman, PhD, Centers for Disease Control and Prevention, Atlanta, GA, USA

External Proficiency Assessment of Prenatal Cell Free (cf )DNA Testing for Aneuploidy

Glenn E. Palomaki, PhD, Women & Infants Hospital, Providence, RI, USA

Duration1.5 hr

Recording Date: November 10, 2016


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NoteJoin the AMP Family to purchase many of the content for a deep discount!

Formats Available: AMP 2016 Highlights - Kalman & Palomaki
Original Course Date: November 10, 2016
On-Demand Release Date: Available Now
MORE INFOMORE INFO AMP 2016 Annual Meeting Highlights - Design, Validation, and Implementation of Effective Quality Control Materials for NGS/NIPS in a Clinical Laboratory
Collapse AMP 2016 Annual Meeting Highlights - Secrets of the Human Genome: The 35-year Journey of Genomic Medicine
Award for Excellence in Molecular Diagnostics

Please note that this webinar was recorded in 2016. All AMPEDTM content is reviewed and approved annually by the Training & Education Committee as relevant and accurate, but new data may now be available and new studies may have since been published.

AMP Education is constantly updating these educational offerings, so keep checking back at educate.amp.org for new content, content updates, and information on cutting-edge molecular pathology research and applications.

This collection will give you access to the recordings of the presentations (listed below) and pdf slides only. CME/CMLE or SAM is not available for this collection


Description:

Did you miss out on joining us in Charlotte for the AMP 2016 Annual Meeting? Were you there but missed something you really wanted to see? We have you covered with the AMP 2016 Annual Meeting Highlights. Select presentations were recorded and are now available for online viewing.

 

This Award for Excellence talk discusses the foundations for discovering the genetic basis of common human diseases including the early development of theoretical methods for mapping the genes underlying polygenic traits; sequencing of the human genome comprehensive discovery of the genetic variation in the human population; systematic characterization of genomic features; and empirical insights into the genetic architecture of common human disease. It describes recent progress in genetic analysis of important diseases such as schizophrenia, heart disease, inflammatory bowel disease and obesity and close by looking forward to the years ahead.

- Recognize the history of discovering the genetic basis of human diseases.

- Analyze the characterization of genetic variation and genomic features.

- Conclude that progress in genomic medicine will be based on emerging discoveries.

Speaker: Eric S. Lander, PhD, Broad Institute of Harvard and MIT, Cambridge, MA, USA

Duration1.25 hr

Recording Date: November 10, 2016

 


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Note: Join the AMP Family to purchase many of the content for a deep discount!

Formats Available: AMP 2016 Highlights - Lander
Original Course Date: November 10, 2016
On-Demand Release Date: Available Now
MORE INFOMORE INFO AMP 2016 Annual Meeting Highlights - Secrets of the Human Genome: The 35-year Journey of Genomic Medicine
Collapse AMP 2016 Annual Meeting Highlights: A View from Across the Pond: European Models for Molecular Infectious Disease Testing

Please note that this webinar was recorded in 2016. All AMPEDTM content is reviewed and approved annually by the Training & Education Committee as relevant and accurate, but new data may now be available and new studies may have since been published.

AMP Education is constantly updating these educational offerings, so keep checking back at educate.amp.org for new content, content updates, and information on cutting-edge molecular pathology research and applications.

This collection will give you access to the recordings of the presentations (listed below) and pdf slides only. CME/CMLE or SAM is not available for this collection


Description:

Did you miss out on joining us in Charlotte for the AMP 2016 Annual Meeting? Were you there but missed something you really wanted to see? We have you covered with the AMP 2016 Annual Meeting Highlights. Select presentations were recorded and are now available for online viewing.

 

A View from Across the Pond: European Models for Molecular Infectious Disase Testing

Speakers will highlight the differences and challenges of European molecular diagnostic approaches compared to those in the U.S. with respect to Clostridium difficile-associated disease and for high-risk HPV detection in cervical cancer screening.

- Outline differences between European diagnostic models compared to the US.

- Describe available tests that have been incorporated into European testing paradigms.

- Identify differences in patient outcomes observed using these different diagnostic practices

Testing Models for Clostridium difficile Infection Used in the UK

Mark Wilcox, MD, FRCPath, Leeds Teaching Hospital & University of Leeds, Leeds, West Yorkshire, UK

HPV Primary Screening: Challenges of Application and Implementation - and Priorities for Research

Kate Cuschieri, BSc, PhD, NHS Lothian, Edinburgh, United Kingdom

 

Duration1.5 hr

Recording Date: November 10, 2016


You might also be interested in:

NoteJoin the AMP Family to purchase many of the content for a deep discount!

 

Formats Available: AMP 2016 Highlights - Wilcox & Cuschieri
Original Course Date: November 10, 2016
On-Demand Release Date: Available Now
MORE INFOMORE INFO AMP 2016 Annual Meeting Highlights: A View from Across the Pond: European Models for Molecular Infectious Disease Testing
Collapse Association for Molecular Pathology v. Myriad Genetics, Inc.

Please note that this webinar was recorded in 2015. All AMPEDTM content is reviewed and approved annually by the Training & Education Committee as relevant and accurate, but new data may now be available and new studies may have since been published.

AMP Education is constantly updating these educational offerings, so keep checking back at educate.amp.org for new content, content updates, and information on cutting-edge molecular pathology research and applications.


Learn about the trial and the seminal ruling of the Association for Molecular Pathology v. Myriad Genetics U.S. Supreme Court case. Hear from one of ACLU's key attorney who handled the case and learn about the implications of the rulings in this two-part webinar.

 

Part 1: Review of the Gene Patent Supreme Court Case

Speakers: Sandra Park, JD

Host: Ted E. Schutzbank, PhD

Duration: 1 hr

Level of Instruction: Basic

 

Part 2: Association for Molecular Pathology v Myriad Genetics, Inc.

Speakers: Sandra Park, JD and Roger D. Klein, MD, JD

Host: Ted E. Schutzbank, PhD

Duration: 1 hr

Level of Instruction: Basic to Intermediate


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All sales are final. No refunds will be issued.

Note: This is a free webinar for all. For access to other webinars at no cost, Join the AMP Family!

Formats Available: Streaming
Original Course Date: June 28, 2013
MORE INFOMORE INFO Association for Molecular Pathology v. Myriad Genetics, Inc.
Collapse Bacterial and Fungal Typing by Sequence-based Methods

Please note that this webinar was recorded in 2016. All AMPEDTM content is reviewed and approved annually by the Training & Education Committee as relevant and accurate, but new data may now be available and new studies may have since been published.

AMP Education is constantly updating these educational offerings, so keep checking back at educate.amp.org for new content, content updates, and information on cutting-edge molecular pathology research and applications.


Description:

This presentation discusses current methods used to identify bacteria by 16S rRNA gene sequencing and fungi by use of the ITS (Internal Transcribed Spacers) and D1/D2 regions, including both technical and bioinformatic analyses. Additional content covers use of these methods to identify pathogens in primary samples, example cases and clinical reporting, potential application of next generation sequencing (NGS)-based methods, and considerations for labs developing and implemeting these assays.

Speaker: Lynn Bry, MD, PhD

Host: Colleen Kraft, MD

Duration: 40 min.

Level of Instruction: Intermediate


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All sales are final. No refunds will be issued.

Note: Members of AMP can access this webinar at no cost. Join the AMP Family!

Formats Available: Bry Presentation
Original Course Date: May 27, 2016
MORE INFOMORE INFO Bacterial and Fungal Typing by Sequence-based Methods
Collapse Next-Generation Sequencing (NGS) Technologies for HIV Drug Resistance Testing

Description:

HIV-1 exists within individuals as a complex mixture of variants often referred to as a quasispecies. During the past 10 years, there have been many studies of the distribution and clinical significance of "low-abundance" or "minority" drug-resistance variants present in plasma in proportions below 20% to 30% -- the limit of detection of standard genotypic resistance testing using dideoxy-terminator "Sanger" sequencing. HIV-1 "deep" sequencing using NGS technologies have been widely used in research settings to study the clinical significance of low-abundance drug resistance mutations. In addition, NGS is commercially available for several niche clinical applications such as determining HIV-1 tropism before using a CCR5 inhibitor.

In this webinar, Dr. Shafer will review the scenarios in which low-abundance HIV-1 drug-resistance mutations are most clinically relevant, the most influential studies of NGS for HIV-1 drug resistance testing, and the practical aspects of NGS that have so far slowed its widespread adoption for most routine HIV-1 genotypic resistance testing.

This content is now FREE for all but, continuing education credit is not available.

 

Speaker: Robert W. Shafer MD

Duration: 1.0 hrs.

Level of Instruction: Basic

Reviewed: March, 2018 

  • The material presented is still relevant.

 

All sales are final. No refunds will be issued.

Members of AMP can access this webinar at no cost. Join the AMP Family!

Formats Available: Streaming
Original Course Date: June 18, 2015
MORE INFOMORE INFO Next-Generation Sequencing (NGS) Technologies for HIV Drug Resistance Testing
Collapse NGS 101: Introduction to the Fundamentals of Next-Generation Sequencing

Description:

Looking to add Next-Generation Sequencing (NGS) to your lab? Familiar with NGS but in need of a refresher? This 5-part series on the fundamentals of NGS is for you! Recorded in 2014 and 2015 “NGS 101” is a comprehensive primer on implementing and running NGS in your lab. To see details on the individual parts of this series, click “Topics."

Duration:  5 hrs

This content is now FREE for all, but continuing education credit is not available.

You can purchase individual sessions or purchase all the chapters.

  • To purchase the entire series, click the "Add to Cart" button located on the right.
  • To purchase individual talks, click on the "Purchase Individual Topics" button on the right, and select the particular session(s) that you would like to purchase.

If you have questions, please email AMPeducation@amp.org

Reviewed: March, 2018

  • This course provides a good overview of basic principles of NGS. However, technologies, platforms, and techniques discussed in the talks are always evolving. Look for an updated NGS course from AMP in the future.

 

All sales are final. No refunds will be issued.

 

Formats Available: Streaming
Original Course Date: December 31, 2015
On-Demand Release Date: Available Now
MORE INFOMORE INFO NGS 101: Introduction to the Fundamentals of Next-Generation Sequencing
Collapse Promises and Pitfalls of Circulating Tumor DNA

Please note that this webinar was recorded in 2016. All AMPEDTM content is reviewed and approved annually by the Training & Education Committee as relevant and accurate, but new data may now be available and new studies may have since been published.

AMP Education is constantly updating these educational offerings, so keep checking back at educate.amp.org for new content, content updates, and information on cutting-edge molecular pathology research and applications.


In oncology, there are a variety of potential clinical applications for a minimally invasive blood test for DNA released from tumor cells. Such applications include detecting early stage disease, tracking response to therapy, prompt identification of disease relapse or recurrence, and recognition of clonal evolution.  Numerous small-scale studies have demonstrated that quantitation of mutations in circulating tumor DNA (ctDNA) is feasible from the blood of cancer patients. The increased adoption of targeted cancer therapies underscores the need to augment invasive tissue biopsies with alternative detection methods that rapidly monitor treatment response. Although most studies have been proof of principle, ctDNA methods hold great promise in cancer diagnostics.

 

Speaker: Christina Lockwood, PhD, DABCC, FACB

Duration: 1.0 hr

Level of Instruction: Intermediate


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All sales are final. No refunds will be issued.

Note: Members of AMP can access this webinar at no cost. Join the AMP Family!

Formats Available: Streaming
Original Course Date: June 09, 2016
MORE INFOMORE INFO Promises and Pitfalls of Circulating Tumor DNA
Collapse Structural Variant Discovery and Considerations for the Clinical Laboratory

Please note that this webinar was recorded in 2016. All AMPEDTM content is reviewed and approved annually by the Training & Education Committee as relevant and accurate, but new data may now be available and new studies may have since been published.

AMP Education is constantly updating these educational offerings, so keep checking back at educate.amp.org for new content, content updates, and information on cutting-edge molecular pathology research and applications.


Description:

In this webinar, Dr. Zehir talks about the structural variation in the genome and the ways it relates to disease formation and treatment. He focuses on the different strategies to detect and visualize them using next-generation sequencing technologies for the clinical laboratory with a focus in cancer. 


Speaker: Ahmet Zehir, PhD

Host: N. Sertac Kip, MD, PhD

Duration: 40 min.

Level of Instruction: Advanced


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All sales are final. No refunds will be issued.

Note: Members of AMP can access this webinar at no cost. Join the AMP Family!

Formats Available: Zehir Presentation
Original Course Date: September 09, 2016
MORE INFOMORE INFO Structural Variant Discovery and Considerations for the Clinical Laboratory
Collapse The Spectrum of Clinical Utilities in Molecular Pathology Testing Procedures for Inherited Conditions and Cancer

Please note that this webinar was recorded in 2016. All AMPEDTM content is reviewed and approved annually by the Training & Education Committee as relevant and accurate, but new data may now be available and new studies may have since been published.

AMP Education is constantly updating these educational offerings, so keep checking back at educate.amp.org for new content, content updates, and information on cutting-edge molecular pathology research and applications.


Recent definitions for clinical utility of molecular tests focus on whether a test result will alter treatment. This definition neglects other uses of molecular testing to diagnose disease, manage symptoms, prognosticate or predict future disease. The fullest realization of precision medicine will require embracing all aspects of clinical utility. This three-part webinar series, supported by AMP, presents the discussions of AMP’s Framework for the Evidence Needed to Demonstrate Clinical Utility (FEND) working group, and its resulting publication, “The Spectrum of Clinical Utilities in Molecular Pathology Testing Procedures for Inherited Conditions and Cancer: A Report of the Association for Molecular Pathology” (Joseph L, et al. J Mol Diagn. 2016;18[5]:605–619).

 

Part 1 - An Overview of AMP’s Framework for the Evidence Needed to Demonstrate Clinical Utility

Speakers: Loren Joseph, MD; Elaine Lyon, PhD

Host: Roger Klein, MD, JD

 

Part 2 - AMP’s Framework for the Evidence Needed to Demonstrate Clinical Utility – Oncology Cases

Speakers: Pranil Chandra, DO, FCAP, FASP; Rajyasree Emmadi, MD, FCAP

Host: Loren Joseph, MD

 

Part 3: AMP’s Framework for the Evidence Needed to Demonstrate Clinical Utility – Inherited Conditions

Speakers: Stephanie Hallam, PhD, FACMG, MBA; Victoria Pratt, PhD, FACMG

Host: Elaine Lyon, PhD

Practice Guideline Available Here

Total Duration: 3 hr

Level of Instruction: Advanced

 

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All sales are final. No refunds will be issued.

Note: Members of AMP can access this webinar at no cost. Join the AMP Family!

Formats Available: Streaming
Original Course Date: September 28, 2016
MORE INFOMORE INFO The Spectrum of Clinical Utilities in Molecular Pathology Testing Procedures for Inherited Conditions and Cancer